Pharmacology Antidepressant Agents 2025 – 400 Free Practice Questions to Pass the Exam

Tricyclic antidepressants (TCAs) are known to block various neurotransmitter receptors in addition to their primary function of inhibiting the reuptake of norepinephrine and serotonin. One of the common side effects associated with this class of medications is dry mouth, also known as xerostomia. This occurs because TCAs can inhibit the action of acetylcholine, which plays a critical role in saliva production. When acetylcholine activity is reduced, patients may experience a decrease in salivary flow, leading to the sensation of dry mouth.

This side effect is significant because it can affect a patient's comfort and adherence to medication. It may lead to difficulties in swallowing, speaking, and can even affect oral hygiene, increasing the risk of dental problems. Understanding this side effect is important for healthcare providers when prescribing TCAs, as they can provide guidance on managing the symptom.